Efficient Synthesis of Spirocyclic Pyrrolidinones via 3+2 Cyclization of α ‐Bromohydroxamates

Key Points

• The study aims to develop an efficient method for synthesizing spirocyclic pyrrolidinones using α-bromohydroxamates.
• Utilized [3+2] cyclization of α-bromohydroxamates with 4-benzylidene-pyrazolones.
• Demonstrated broad substrate scope and excellent functional group tolerance.
• Successfully scaled the synthesis to gram-scale.
• Achieved rapid assembly of spiro-pyrrolidinones.
• Showed the method's effectiveness for a wide range of substrates.
• Established the scalability of the synthetic protocol.