Risk factors for in vivo emergence of ceftazidime-avibactam resistance in KPC-producing Klebsiella pneumoniae and the associated resistance mechanisms: a case-control study

Key Points

• This research aims to identify risk factors associated with the emergence of ceftazidime-avibactam resistance in Klebsiella pneumoniae.
• Case-control design comparing patients with and without ceftazidime-avibactam resistance.
• Analysis of infection and resistance mechanisms in KPC-producing Klebsiella pneumoniae.
• Data collection on clinical and microbiological profiles.
• Identified specific risk factors contributing to resistance emergence.
• Demonstrated association between certain clinical variables and increased resistance rates.
• Provided insights into the mechanisms underpinning ceftazidime-avibactam resistance.

Abstract