The building blocks of phage therapy: from lytic phage identification to preclinical validation against antimicrobial-resistant critical priority bacteria

Key Points

• To explore the identification and validation of lytic phages for therapy against resistant bacteria.
• Identified promising lytic phages through isolation and characterization
• Conducted preclinical validation using a mouse model
• Evaluated phages' effects on survival against antimicrobial-resistant bacteria
• One phage significantly enhanced survival in the mouse model
• Study outlines a roadmap for phage therapy development
• Demonstrated therapeutic potential of specific phages against critical bacteria