Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during pregnancy raises concerns regarding maternal and neonatal outcomes. However, the relevant regional data remain limited in Saudi Arabia. Methods: This single-centre retrospective cohort study enrolled pregnant women with confirmed SARS-CoV-2 infection from Prince Sultan Military Medical City, Riyadh, Saudi Arabia, between March 2020 and March 2022. Data on demographic characteristics, clinical presentation, vaccination status, obstetric outcomes, maternal complications, and neonatal outcomes were extracted from their electronic medical records and analysed descriptively. Associations between vaccination status and obstetric outcomes were assessed using Fisher’s exact test. Results: This study included 414 pregnant women. Most patients were asymptomatic (82.1%) and unvaccinated (95.9%). In addition, 84.8% had a normal vaginal delivery, whereas 1.7% had a spontaneous preterm birth. Maternal complications were rare, including intensive care unit (ICU) admission (0.5%) and mechanical ventilation (0.2%). Perinatal outcomes included stillbirths (3.4%), abortions (1.2%), and neonatal deaths (0.5%). Neonatal SARS-CoV-2 positivity was detected in 1.9% of neonates. No significant association was found between vaccination status and obstetric outcomes ( P = 0.789). Conclusions: In this cohort, the pregnant women with SARS-CoV-2 infection were predominantly asymptomatic. This infection was associated with favourable maternal and neonatal outcomes. Vertical transmission was infrequent and was not associated with severe neonatal morbidity.
Alsaeed et al. (Thu,) studied this question.