Abstract Personalizing treatment in oncological neurosurgery presents significant challenges due to the unique characteristics and medical histories of each patient. Basaloid squamous cell carcinoma (BSCC) in the nasal cavity with brain invasion is a rare complication that complicates standard treatment approaches. The aim is to describe the multidisciplinary surgical management of a patient with BSCC in the nasal cavity extending to the brain and to discuss therapeutic options based on our experience and a literature review. We report the case of a 49-year-old woman with progressive symptoms over three months, including intense headaches and visual impairment. Imaging revealed an occupying lesion extending from the nasal cavity to the brain. Surgical resection was performed using a combined frontal and endoscopic transnasal approach. Histopathology confirmed the diagnosis of BSCC. Post-operative recovery was noted with residual facial pain and limited visual function. The treatment included surgical resection followed by targeted chemotherapy. Few similar cases have been reported, making standardized treatment protocols challenging. The management of BSCC in the nasal cavity with brain invasion presents unique clinical challenges due to its rarity and the complex anatomy of the involved areas. Our case adds to the limited reports of BSCC in the nasal cavity with brain invasion, a condition for which standardized treatment protocols have yet to be established. The complexity of this case required a multidisciplinary approach involving otolaryngologists, neurosurgeons, oncologists, and radiologists. This collaborative effort was crucial not only in the meticulous planning and execution of the surgical strategy but also in tailoring adjuvant therapy post-surgery. Significant challenges were faced in managing the extensive intracranial invasion. Advanced imaging techniques were pivotal in planning the surgical route and extent of resection.
Hernandez et al. (Mon,) studied this question.