Green-synthesized Matricaria chamomilla silver nanoparticles enhance anticonvulsant and neuroprotective effects through GABAergic and antioxidant pathways in an acute seizure rat model

Key Points

• This research aims to assess the anticonvulsant and neuroprotective effects of silver nanoparticles derived from Matricaria chamomilla.
• Acute seizure rat model using PTZ to induce seizures
• Comparison of green-synthesized silver nanoparticles and crude extract
• Assessment of GABAergic signaling and antioxidant defenses
• Silver nanoparticles significantly reduced PTZ-induced seizures
• Demonstrated enhanced neuroprotection against neuronal damage
• Outperformed the crude extract in anticonvulsant effects