A dual-network SIS collagen/chitosan hydrogel with integrated antibacterial and regenerative functions for infected wound repair

Key Points

• To explore a dual-network hydrogel's potential for repairing infected wounds with antibacterial and regenerative functions.
• Developed a dual-crosslinked hydrogel using SIS collagen and chitosan.
• Evaluated the antibacterial and regenerative properties of the hydrogel in vitro and in vivo.
• Compared the hydrogel's effectiveness to traditional wound dressings.
• The dual-network hydrogel exhibited significant antibacterial activity against common pathogens.
• The hydrogel promoted faster wound healing compared to control dressings.
• SIS collagen and chitosan synergistically improved the regenerative properties of the dressing.