Safety Letter: Non-Pyrophoric tert- Butyllithium in Base Oils: Preparation by Mechanochemistry and Conventional Methods and Use in Activating Alkylboronic Esters

Key Points

• This letter addresses the preparation and application of non-pyrophoric tert-butyllithium in base oils.
• Preparation via mechanochemistry and conventional methods
• Utilization of lithium metal and butyl chloride
• Comparison of solvent-swapping strategies
• Demonstrates safe and selective alkylboronic ester transformations
• Highlights efficiency of different preparation methods