Altered crosstalk of bacterial lipopolysaccharide with immune cells in colorectal cancer compared to paired adjacent intestinal tissue

Key Points

• The research aims to compare immune cell interactions in colorectal cancer and adjacent intestinal tissues.
• Analyzed immune cell composition in colorectal cancer and adjacent tissues.
• Examined the colocalization of neutrophils with bacterial lipopolysaccharide (LPS).
• Investigated immune cell-bacteria interactions.
• Assessed differences between tumor and adjacent tissue immune environments.
• Increased neutrophil colocalization with LPS in tumor tissues.
• Distinct immune cell compositions between colorectal tumors and adjacent tissues.
• Insights into host-microbiota dynamics were offered.