Resource efficiency has become a key criterion in evaluating methods of analytical chemistry. Microfluidic paper-based analytical devices generally meet this criterion. This article provides an overview of the main approaches to the development and application of microfluidic paper-based analytical devices as tools for resource-efficient chemical analysis. Fundamental principles of the design of such systems are discussed, including various methods of the formation of hydrophobic barriers on the paper surface and methods for recording the analytical signal (digital colorimetry, fluorescence and electrochemical detection). Potentials for combining these detection methods with paper microfluidic systems in the development of rapid, portable, and inexpensive screening assays are demonstrated.
Furletov et al. (Wed,) studied this question.