Unraveling prothionamide solubility enhancement by ionic liquids: from molecular screening to microscopic insights

Key Points

• The aim is to improve the aqueous solubility of prothionamide, a poorly soluble anti-tuberculosis medication, using ionic liquids.
• Utilized ionic liquid technology for enhancing solubility.
• Conducted molecular screening of prothionamide in various ionic liquids.
• Assessed solubility improvements through microscopic insights.
• Demonstrated significant enhancement of prothionamide solubility with selected ionic liquids.
• Achieved measurable increases in solubility metrics, though specific values are not provided.