Redefining the Standard of Care in Deep Burns: Autologous Skin Grafts Versus Next-Generation Bioengineered Skin Substitutes A Contemporary Systematic Review

Key Points

• The aim is to evaluate the effectiveness of autologous skin grafts compared to bioengineered skin substitutes for treating deep burns.
• Conducted a systematic review of three studies with approximately 297 participants.
• Compared early graft take rates between STSG and bioengineered skin substitutes.
• Assessed outcomes related to the need for autografts and scarring.
• STSG showed better early graft take compared to bioengineered substitutes.
• Bioengineered substitutes reduced the need for autografts and provided expansion benefits.
• Healing with bioengineered substitutes may be slower and requires larger trials for validation.