Enabling Access to sp 3 ‐Enriched Targeted Protein Degraders via Redox‐Neutral Radical Cross‐Coupling

Key Points

• The study aims to explore methods for accessing sp3-enriched targeted protein degraders through innovative coupling techniques.
• Utilized redox-neutral radical cross-coupling to synthesize glutarimides.
• Examined the degradation of BRD4 mediated by CRBN mechanisms.
• Demonstrated effective degradation of BRD4 with CRBN-dependent pathways.
• Highlighted the translational potential of glutarimides in drug development.