Thioureas as a potential therapeutic strategy for severe pulmonary tuberculosis: in vitro and in vivo antimycobacterial and anti-inflammatory ativity

Key Points

• Investigate the therapeutic potential of thioureas for severe pulmonary tuberculosis through in vitro and in vivo assessments.
• Conducted in vitro and in vivo experiments to evaluate antimycobacterial and anti-inflammatory activities of thioureas.
• Included qualitative and quantitative analyses of the response to treatment.
• Assessed the effects on tuberculosis over a defined period.
• Thioureas demonstrated significant antimycobacterial activity in vitro with promising results in vivo.
• The anti-inflammatory effects were also notable, potentially aiding recovery in pulmonary tuberculosis.
• Further quantitative results were examined, leading to implications for clinical application.