Effect of nortriptyline on inhibitory synaptic transmission within the substantia gelatinosa of the trigeminal subnucleus caudalis in mice

Key Points

• This study aims to assess how nortriptyline influences inhibitory synaptic transmission within a specific brain region in mice.
• Assessed the effect of nortriptyline on synaptic activity in the substantia gelatinosa of the trigeminal subnucleus caudalis.
• Utilized in vivo techniques to evaluate changes in inhibitory transmission.
• Focused on nociceptive processing in the orofacial region.
• Nortriptyline significantly increased inhibitory synaptic transmission in the studied brain region.
• Demonstrated a modulation pattern indicating enhanced pain processing related to orofacial stimuli.