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May 8, 2026

Intramolecular difunctionalization of alkynes involving cascade radical 1,4-heteroaryl migrations and formal total synthesis of a β-imidazolyl-γ-lactam alkaloid: isoanantine

Key Points

This research aims to develop a method for the intramolecular difunctionalization of alkynes, focusing on synthesizing β-heteroaryl-γ-lactams.
Explored multiple versions of intramolecular difunctionalization of alkynes.
Utilized various 1,4-heteroaryl migrations during the process.
Investigated five nitrogen-containing heteroaromatics.
Successfully produced a series of β-heteroaryl-γ-lactams.
Demonstrated effective radical migrations.
Provided a formal total synthesis pathway for isoanantine.

Abstract

Several versions of the intramolecular difunctionalization of alkynes involving a variety of 1,4-heteroaryl migrations were explored to produce a series of β-heteroaryl-γ-lactams. Five nitrogen-containing heteroaromatics were used to investigate group...

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Authors

Yu-Tong Huang

Fu Jen Catholic University

Che‐Chien Chang

Fu Jen Catholic University

Journals

Organic & Biomolecular Chemistry

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Intramolecular difunctionalization of alkynes involving cascade radical 1,4-heteroaryl migrations and formal total synthesis of a β-imidazolyl-γ-lactam alkaloid: isoanantine

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Abstract

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