This longitudinal, prospective, multicenter observational cohort study investigates the associations between maternal nutritional status-assessed using the first trimester SIMPLE score and pregestational BMI-and fetal growth trajectories and velocity, as proxies for intrauterine development. Healthy women with singleton pregnancies undergoing first trimester screening were enrolled. Adherence to a healthy lifestyle was evaluated using the SIMPLE score, categorizing participants into low (110 g/l] and EFW growth velocity. Overall, these findings confirm the clinical utility of the SIMPLE score, demonstrating significant associations with intrauterine growth trajectories and velocity, independent of other markers of nutritional status (e.g., pregestational BMI).
Parisi et al. (Wed,) studied this question.