What question did this study set out to answer?

This research aims to determine if specific transgelin-derived neo-fragments are detectable in menstrual blood from patients with adenomyosis.

May 8, 2026Open Access

TAGLN-NeoLib: A falsifiable targeted LC-MS/MS discovery hypothesis for menstrual transgelin neo-fragments in adenomyosis

Key Points

This research aims to determine if specific transgelin-derived neo-fragments are detectable in menstrual blood from patients with adenomyosis.
Utilized a targeted LC-MS/MS approach to analyze menstrual blood samples.
Included clinically relevant comparator groups to assess neo-fragment presence.
Established strict Go/No-Go rules before potential immunoassay development.
Proposed neo-fragments are expected to be reproducibly enriched in menstrual blood from adenomyosis patients.
Validation as a diagnostic biomarker is not claimed at this stage.
The approach emphasizes the necessity of robustness in result reproducibility before further development.

Abstract

TAGLN-NeoLib is an original research hypothesis and targeted biomarker-discovery brief. It proposes to test whether selected transgelin/TAGLN-derived candidate neo-fragments are detectable, reproducible, and relatively enriched in menstrual blood from patients with adenomyosis using targeted LC-MS/MS. The project does not claim a validated diagnostic biomarker and does not propose to measure total TAGLN. The proposed strategy includes clinically relevant comparator groups and strict Go/No-Go rules before any conditional immunoassay development.

TAGLN-NeoLib: A falsifiable targeted LC-MS/MS discovery hypothesis for menstrual transgelin neo-fragments in adenomyosis

Key Points

Abstract

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