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ADVERTISEMENT RETURN TO ISSUEPerspectiveNEXTMedicinal Chemistry of hERG Optimizations: Highlights and Hang-UpsCraig Jamieson, Elizabeth M. Moir, Zoran Rankovic, and Grant WishartView Author Information Medicinal Chemistry, Organon Laboratories Ltd., Newhouse, Lanarkshire ML1 5SH, Scotland, U.K. Cite this: J. Med. Chem. 2006, 49, 17, 5029–5046Publication Date (Web):July 27, 2006Publication History Received31 March 2006Published online27 July 2006Published inissue 1 August 2006https://pubs.acs.org/doi/10.1021/jm060379lhttps://doi.org/10.1021/jm060379lreview-articleACS PublicationsCopyright © 2006 American Chemical SocietyRequest reuse permissionsArticle Views10346Altmetric-Citations366LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Modification,Optimization,Partition coefficient,Redox reactions,Selectivity Get e-Alerts
Jamieson et al. (Thu,) studied this question.