What question did this study set out to answer?

The study aims to identify how serotonin receptor maps influence brain dynamics under the effect of LSD.

September 27, 2018Open Access

Whole-Brain Multimodal Neuroimaging Model Using Serotonin Receptor Maps Explains Non-linear Functional Effects of LSD

Key Points

The study aims to identify how serotonin receptor maps influence brain dynamics under the effect of LSD.
Developed a multimodal neuroimaging model incorporating serotonin receptor maps.
Analyzed interactions between neuronal systems and neurotransmitter distributions.
Investigated effects on brain connectivity and dynamics.
Identified specific anatomical connectivity influencing LSD's non-linear effects.
Found distinct patterns in neurotransmitter receptor density affecting brain functions.
Demonstrated that neuromodulatory activity is crucial for understanding global brain dynamics.

Abstract

R density. The model identified the causative mechanisms for the non-linear interactions between the neuronal and neurotransmitter system, which are uniquely linked to (1) the underlying anatomical connectivity, (2) the modulation by the specific brainwide distribution of neurotransmitter receptor density, and (3) the non-linear interactions between the two. Taking neuromodulatory activity into account when modeling global brain dynamics will lead to novel insights into human brain function in health and disease and opens exciting possibilities for drug discovery and design in neuropsychiatric disorders.

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