Learning-aided design of micropost arrays for optimizing interface stability and mass transport in organs-on-chips

Key Points

• The aim is to enhance interface stability and mass transport in micropost-based organ-on-chip systems.
• Utilized learning-aided design techniques to configure micropost arrays efficiently
• Created 3D co-culture microenvironments using cell-laden hydrogels
• Evaluated transport dynamics and stability under various design configurations
• Achieved significant improvements in mass transport efficiency, reflected in stable interface dynamics
• Micropost designs resulted in enhanced cell viability and function within the 3D microenvironments