What question did this study set out to answer?

This study aims to assess the significance of SLC2A3 expression in predicting liver metastasis and postoperative outcomes in colorectal cancer patients.

May 10, 2026Open Access

SLC2A3 Expression is Differentially Associated with Postoperative Recurrence, Complications, and Liver Metastasis in Colorectal Cancer

Key Points

This study aims to assess the significance of SLC2A3 expression in predicting liver metastasis and postoperative outcomes in colorectal cancer patients.
Retrospective cohort study of 150 colorectal cancer patients post-surgery.
Quantitative real-time PCR measured SLC2A3 mRNA in tumor and adjacent normal tissues.
Multivariable logistic regression analyzed associations between SLC2A3 expression and postoperative outcomes.
SLC2A3 mRNA expression was significantly higher in tumor tissues compared to normal tissues (P < 0.001).
Elevated SLC2A3 expression linked to increased liver metastasis, postoperative recurrence, and complications.
After adjustment, SLC2A3's connection to liver metastasis was less pronounced, highlighting its strong association with recurrence and complications.

Abstract

Objective: To evaluate the clinical significance of solute carrier family 2 member 3 (SLC2A3) expression in predicting liver metastasis, postoperative recurrence, and other postoperative complications in patients with colorectal cancer (CRC). Methods: This was a retrospective cohort study including 150 patients with CRC who underwent surgical treatment. Bioinformatics analyses were conducted to identify differentially expressed genes associated with CRC liver metastasis, from which SLC2A3 was identified as a key candidate. SLC2A3 mRNA expression in tumor and adjacent normal tissues was quantified using quantitative real-time PCR. Patients were stratified according to liver metastasis, postoperative recurrence, and postoperative complications. Multivariable logistic regression models were applied to evaluate independent associations between SLC2A3 expression and postoperative outcomes. Results: SLC2A3 mRNA expression was significantly upregulated in CRC tumor tissues compared with adjacent normal tissues (P < 0.001). Elevated SLC2A3 expression was associated with liver metastasis, postoperative recurrence, and postoperative complications. In multivariable logistic regression analyses, SLC2A3 expression remained independently associated with postoperative recurrence and complications, while its association with liver metastasis was attenuated after adjustment for tumor differentiation. Conclusion: SLC2A3 expression is closely associated with adverse postoperative outcomes in CRC. While its association with liver metastasis appears partly mediated by tumor differentiation, SLC2A3 demonstrates potential as an independent marker, highlighting its potential value in postoperative risk stratification and prognostic assessment. However, these findings should be interpreted with caution due to the retrospective design and lack of external validation. Keywords: colorectal cancer, SLC2A3, liver metastasis, postoperative recurrence, postoperative complications, prognosis

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Cite This Study

Peng et al. (Fri,) studied this question.

synapsesocial.com/papers/6a0021fec8f74e3340f9cebc https://doi.org/https://doi.org/10.2147/cmar.s594748

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