April 28, 2022Open Access

Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms

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Abstract

-RdRp consensus sequences in the absence of RDV selection. The results define genetic and biochemical pathways to RDV resistance and emphasize the need for additional studies to define the potential for emergence of these or other RDV resistance mutations in clinical settings.

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Stevens et al. (Thu,) studied this question.

synapsesocial.com/papers/6a0146932ff633f3657853ad https://doi.org/https://doi.org/10.1126/scitranslmed.abo0718

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