What is the clinical evidence from this study?

Study design: Other. Population: Enterovirus-A71 infection.

What question did this study set out to answer?

To clarify the mechanisms by which Enterovirus-A71 invades the central nervous system via peripherin and Rac1.

February 28, 2026Open Access

Author Correction: Enterovirus-A71 exploits peripherin and Rac1 to invade the central nervous system

Key Result

The authors issued a correction to replace an incorrectly sized image in Figure 3C and update the figure legend to reflect cell fixation at 24 hours post-infection instead of 48 hours.

Key Points

To clarify the mechanisms by which Enterovirus-A71 invades the central nervous system via peripherin and Rac1.
Correction of previously published findings regarding viral mechanisms of CNS invasion.
Discussion on the role of peripherin and Rac1 in viral entry pathways.
Enterovirus-A71 utilizes peripherin for binding and entry into neuronal cells.
Rac1 is implicated in facilitating the invasion process of the virus into the central nervous system.

Structured PICO

Population

NSC-34 and SH-SY5Y cells

Intervention

Infection with EV-A71 S41 at MOI 10 and 0.01

Outcome

Proximity ligation assay staining using anti-PRPH and anti-VP0 antibodies

This is an author correction for a previously published paper regarding an image and legend inaccuracy.

Abstract

Image: see text

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Cite This Study

Lim et al. (Tue,) conducted a other in Enterovirus-A71 infection. The authors issued a correction to replace an incorrectly sized image in Figure 3C and update the figure legend to reflect cell fixation at 24 hours post-infection instead of 48 hours.

synapsesocial.com/papers/6a025a459cddff7633412ace https://doi.org/https://doi.org/10.1038/s44319-026-00722-7

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