What question did this study set out to answer?

The aim is to develop a lung tumoroid-on-chip model to accurately evaluate the effectiveness of anti-invasion agents.

May 14, 2026Advanced Functional Materials0 citations

A Vascularized Lung Tumoroid‐on‐Chip Model for the Accurate Assessment of Anti‐Invasion Agents (Adv. Funct. Mater. 37/2026)

XWXuerui WangShanghai University of Traditional Chinese Medicine GZGuang ZhuDepartment of Primary Industries and Regions South Australia JLJinnuo LuShanghai University of Traditional Chinese Medicine

Key Points

The aim is to develop a lung tumoroid-on-chip model to accurately evaluate the effectiveness of anti-invasion agents.
Developed a lung tumoroid-on-chip model that simulates vascular invasion.
Utilized this model to predict drug efficacy against tumor metastasis.
Evaluated the response of the tumoroid to potential anti-invasion treatments.
The tumoroid-on-chip effectively mimics vascular invasion in lung cancer.
The model indicates promising drug efficacy in inhibiting tumor metastasis.
Findings suggest potential for accurate prediction of treatment effectiveness.

Abstract

Tumoroid-on-Chip Model The cover illustrates a lung tumoroid-on-a-chip model used to simulate vascular invasion, forming a lung cancer mosaic vessel, which is a sensitive indicator to predict drug efficacy (depicted as golden bombs) in inhibiting tumor metastasis. More information can be found in the Research Article by Chih-Tsung Yang, Zhaobin Guo, Guangbo Ge, and co-workers (DOI: 10.1002/adfm.202526981).

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