January 1, 2005

Splicing of a rare class of introns by the U12-dependent spliceosome

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Abstract

Pre-mRNA splicing is catalyzed by two unique spliceosomes, designated U2- or U12-dependent. In contrast to the well-characterized U2-dependent spliceosome, much remains to be learned about the less abundant U12-type spliceosome. This review focuses on recent advances in elucidating the structure and function of the minor U12-dependent spliceosome. Interesting similarities and differences between the U12- and U2-dependent spliceosomes are also highlighted.

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Will et al. (Sat,) studied this question.

synapsesocial.com/papers/6a067b47bb584440490253bc https://doi.org/https://doi.org/10.1515/bc.2005.084

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome2004 · 166 citations
2Splicing double: insights from the second spliceosome2003 · 468 citations
3Proximity of the U12 snRNA with both the 5′ Splice Site and the Branch Point during Early Stages of Spliceosome Assembly2005 · 15 citations
4U4 small nuclear RNA can function in both the major and minor spliceosomes2003 · 20 citations
5Conserved Sequences in a Class of Rare Eukaryotic Nuclear Introns with Non-consensus Splice Sites1994 · 240 citations

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