Upregulation of ADAM10 reinforces CD8 + T cells toward exhaustion in the TME

Key Points

• Investigate the role of ADAM10 in the function of CD8+ T cells within the tumor microenvironment.
• Utilized in vivo models of solid tumors to assess CD8+ T cell functionality.
• Analyzed the impact of ADAM10 upregulation on T cell exhaustion in the TME.
• Upregulation of ADAM10 significantly increased markers of CD8+ T cell exhaustion.
• Cytotoxic function of CD8+ T cells was markedly inhibited in the presence of an immunosuppressive TME.