Protein Kinase A was identified as a modulator of microtubule repolymerization in hypertrophic cardiomyopathy using phosphoproteomics and a novel hiPSC-CM model.
Background and aims: Increased levels of α-tubulin and its post-translational modifications (PTMs) are found in human heart failure and could initiate diastolic dysfunction by modulating cardiomyocyte stiffness. How these modifications occur and how they may underlie cardiac dysfunction remains unknown. Upstream kinases may play a critical role, but this has not been explored. Methods and results: as potential MT modifiers in HCM. Conclusions: created with BioRender.com.
Algul et al. (Fri,) conducted a other in Hypertrophic Cardiomyopathy. Protein Kinase A was identified as a modulator of microtubule repolymerization in hypertrophic cardiomyopathy using phosphoproteomics and a novel hiPSC-CM model.