Anaemia was associated with higher all-cause mortality compared to no anaemia (30% vs. 14%, p < 0.001) but was not an independent predictor of death in multivariate analysis.
Cohort (n=434)
Does anaemia independently predict all-cause mortality in patients with acute or chronic heart failure?
Anaemia in heart failure acts as a marker of disease severity and congestion rather than an independent predictor of mortality.
Effect estimate: HR 2.6
Absolute Event Rate: 30% vs 14%
p-value: p=<0.001
The aim of this study was to evaluate the relationship between anaemia and biomarkers of central/peripheral congestion in heart failure (HF) and the impact on mortality. We retrospectively evaluated 434 acute/chronic HF (AHF/CHF) patients. Anaemia was defined as haemoglobin levels <12 g/dL (women) or <13 g/dL (men). The brain natriuretic peptide (BNP) and hydration index (HI) were measured. The endpoint of the study was all-cause mortality. Anaemia occurred in 59% of patients with AHF and in 35% with CHF (p < 0.001) and showed a significant correlation with the NYHA functional class and renal function. BNP and HI were significantly higher in patients with anaemia than in those without anaemia. Independent predictors of anaemia included BNP, estimated creatinine clearance (eCrCL), and HI. The all-cause mortality rate was 21%, which was significantly higher in patients with anaemia than in those without anaemia (30% vs. 14%, p < 0.001; hazard ratio: 2.6). At multivariate Cox regression analysis, BNP, eCrCL, and HI were independent predictors for mortality (Hazard ratios: 1.0002, 0.97, and 1.05, respectively), while anaemia was not. Anaemia correlates with HF status, functional class, renal function, BNP, and HI. Anaemia was not an independent predictor for mortality, acting as a disease severity marker in congestive patients rather than as a predictor of death.
Scicchitano et al. (Tue,) conducted a cohort in Acute/chronic heart failure (n=434). Anaemia vs. No anaemia was evaluated on All-cause mortality (HR 2.6, p=<0.001). Anaemia was associated with higher all-cause mortality compared to no anaemia (30% vs. 14%, p < 0.001) but was not an independent predictor of death in multivariate analysis.