Baseline heart rate Z-score significantly modified the early postoperative trajectory of rate-pressure product in children receiving dexmedetomidine-sufentanil sedation (interaction p<0.001).
Cohort (n=96)
No
Is baseline heart rate Z-score associated with early postoperative trajectories of rate-pressure product, heart rate, and mean arterial pressure in children receiving dexmedetomidine and sufentanil sedation after transcatheter closure?
Baseline heart rate Z-score is associated with early postoperative myocardial workload trajectory in children after transcatheter closure under dexmedetomidine and sufentanil sedation, which may help guide monitoring intensity.
p-value: p=<0.001
Background Dexmedetomidine (DEX) plus sufentanil (SF) sedation is commonly used after transcatheter closure for simple congenital heart disease (CHD), yet early hemodynamic responses vary. Absolute heart rate (HR) values are not comparable across pediatric ages; an age-standardized HR Z -score may better contextualize baseline HR status. Objective To evaluate the association between baseline HR Z -score and early postoperative trajectories of rate–pressure product (RPP), HR, and mean arterial pressure (MAP) under a standardized DEX + SF pathway, and to describe safety outcomes. Methods We retrospectively studied 96 children (0–16 years) admitted to the PICU after transcatheter closure (June 2023–August 2025). Hemodynamics were recorded at admission (T0), 1 h, 4 h, and 8 h. Longitudinal associations were assessed using linear mixed models including time, HR Z -score, and a time × Z -score interaction, with age as a covariate, with sensitivity analyses. Results RPP decreased over time and showed a significant time × HR Z -score interaction, indicating that baseline HR Z -score modified the early postoperative RPP trajectory. The corresponding interaction was significant for HR but not for systolic blood pressure or MAP, consistent with HR-driven differences, while SBP/MAP interactions were not statistically significant in this cohort. Bradycardia occurred in 9/96 patients (9.4%), and no hypotension events were observed. Conclusion Baseline HR Z -score, as an approximate age-standardized index of heart rate, is associated with early postoperative myocardial workload trajectory after transcatheter closure under DEX + SF sedation, primarily via HR reduction, and may help guide monitoring intensity.
Li et al. (Mon,) conducted a cohort in Simple congenital heart disease (CHD) (n=96). Baseline heart rate Z-score (under standardized dexmedetomidine and sufentanil sedation) vs. Comparison across HR Z-score strata (Low-Z, Normal-Z, High-Z) was evaluated on Trajectory of rate-pressure product (RPP) over 8 hours (p=<0.001). Baseline heart rate Z-score significantly modified the early postoperative trajectory of rate-pressure product in children receiving dexmedetomidine-sufentanil sedation (interaction p<0.001).