Immediate coronary angioplasty after intravenous tissue plasminogen activator was associated with increased mortality and need for emergency bypass surgery compared to deferred angioplasty.
Systematic Review
Does immediate coronary angioplasty after intravenous tissue plasminogen activator improve outcomes compared to deferred angioplasty in patients with acute myocardial infarction?
Immediate coronary angioplasty after thrombolytic therapy for acute myocardial infarction is associated with worse outcomes compared to a deferred strategy.
PURPOSE: To critically review the role of coronary angioplasty for acute myocardial infarction. DATA IDENTIFICATION: Studies published from January 1982 to June 1988 were identified through a search of the English-language literature using MEDLINE and thorough extensive hand searching of bibliographies of identified articles. STUDY SELECTION: All consecutive patient series and randomized trials of coronary angioplasty for acute myocardial infarction. DATA EXTRACTION: Demographic characteristics, technical results, clinical outcomes, and left ventricular function results were collated. RESULTS OF DATA SYNTHESIS: Three randomized trials have compared immediate and deferred coronary angioplasty after intravenous tissue plasminogen activator. Immediate angioplasty was associated with increased mortality, increased need for emergency bypass surgery, higher transfusion requirement, and no benefit in terms of left ventricular functional recovery. CONCLUSIONS: The role of coronary angioplasty for myocardial infarction has thus far been established as adjunctive, in a delayed time frame after thrombolytic therapy. Coronary angioplasty has not been shown to reduce in-hospital mortality or improve resting left ventricular function. A deferred strategy has improved exercise left ventricular performance, and several follow-up studies suggest a favorable long-term prognosis.
Eric J. Topol (Thu,) conducted a systematic review in Acute myocardial infarction. Immediate coronary angioplasty vs. Deferred coronary angioplasty was evaluated on Mortality, need for emergency bypass surgery, transfusion requirement, and left ventricular functional recovery. Immediate coronary angioplasty after intravenous tissue plasminogen activator was associated with increased mortality and need for emergency bypass surgery compared to deferred angioplasty.