OBJECTIVE: Platelet-rich plasma (PRP) is currently utilized in several clinical fields, including infertility treatment. This study aimed to evaluate the effectiveness of intraovarian PRP injections in improving reproductive outcomes in women who have previously experienced unsuccessful IVF cycles. METHODS: In this Open-label Single-Arm Longitudinal clinical trial study, a number of 15 infertile patients, POSEIDON groups 1 and 3 (poor ovarian reserve), with no history of hematological, immunological, hormonal disorders, chromosomal and genetic abnormalities, and kidney failure were investigated. PRP was prepared using a standardized protocol and administered at a dose of 2.5 cc per ovary. Key reproductive parameters, including follicle development, oocyte quality, embryo formation, and endometrial thickness were measured before PRP treatment, immediately after treatment, and three months post-treatment. After collecting and sorting, the data was analyzed using SPSS Ver.26 statistical software. RESULTS: Nearly 27% of the participants achieved pregnancy, despite previous IVF failures. The findings revealed significant improvements in the median number of follicles larger than 17 millimeters, the number of oocytes, fertilizable oocytes, and endometrial thickness following PRP treatment (p<0.05). The number of embryos formed, as well as the frequency of A or B grade embryos, also increased significantly at three months post-PRP (p<0.001). CONCLUSIONS: Intraovarian PRP injections show potential as an effective treatment for improving reproductive outcomes in women with a history of IVF failures. However, further research with larger sample sizes, control groups, and extended follow-up periods is needed to validate these findings and establish PRP as a standard therapy in reproductive medicine.
Usefi et al. (Fri,) studied this question.