Cardiac fibroblasts act as the primary source of outgoing signals to other cell types, orchestrating intercellular communication that maintains organ homeostasis and contributes to disease states.
Cardiac fibroblasts play a key role in orchestrating intercellular communication with cardiomyocytes, endothelial cells, and immune cells in both healthy and diseased states.
Cardiac fibroblasts constitute a major cell population in the heart. They secrete extracellular matrix components and various other factors shaping the microenvironment of the heart. In silico analysis of intercellular communication based on single‐cell RNA sequencing revealed that fibroblasts are the source of the majority of outgoing signals to other cell types. This observation suggests that fibroblasts play key roles in orchestrating cellular interactions that maintain organ homeostasis but that can also contribute to disease states. Here, we will review the current knowledge of fibroblast interactions in the healthy, diseased, and aging heart. We focus on the interactions that fibroblasts establish with other cells of the heart, specifically cardiomyocytes, endothelial cells and immune cells, and particularly those relying on paracrine, electrical, and exosomal communication modes.
Nicin et al. (Wed,) conducted a review in Healthy and diseased heart. Cardiac fibroblasts act as the primary source of outgoing signals to other cell types, orchestrating intercellular communication that maintains organ homeostasis and contributes to disease states.
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