3.0-T MRI measurements of common carotid mean wall thickness were highly correlated with B-mode ultrasound intima-media thickness (r=0.89, P<0.001), with MRI demonstrating smaller variability.
Observational (n=45)
Does 3.0-T MRI measurement of carotid mean wall thickness correlate with B-mode ultrasound intima-media thickness in healthy volunteers and patients with cardiovascular disease?
3.0-T MRI provides highly reproducible measurements of carotid artery wall thickness that correlate strongly with ultrasound IMT, potentially allowing for smaller sample sizes in cardiovascular prevention trials.
Effect estimate: r=0.89
Absolute Event Rate: 0.711% vs 0.8%
p-value: p=<0.001
BACKGROUND: Our aim was to compare common carotid mean wall thickness (MWT) measurements by 3.0-T MRI with B-mode ultrasound common carotid intima-media thickness (CCIMT) measurements, a validated surrogate marker for cardiovascular disease. METHODS AND RESULTS: B-mode ultrasound and 3.0-T MRI scans of the left and right common carotid arteries were repeated 3 times in 15 healthy younger volunteers (age, 26+/-2.6 years), 15 healthy older volunteers (age, 57+/-3.2 years), and 15 subjects with cardiovascular disease and carotid atherosclerosis (age, 63+/-9.8 years). MWT was 0.711 (SD, 0.229) mm and mean CCIMT was 0.800 (SD, 0.206) mm. MWT and CCIMT were highly correlated (r=0.89, P<0.001). The intraclass correlation coefficients for interscan and interobserver and intraobserver agreements of MRI MWT measurements were larger than 0.95 with small confidence intervals, indicating excellent reproducibility. Power calculations indicate that 89 subjects are required to detect a 4% difference in MRI MWT compared with 469 subjects to detect similar differences with ultrasound IMT in follow-up studies. CONCLUSIONS: The study data for carotid MRI and ultrasound IMT showed strong agreement, indicating that both modalities measure the thickness of the intima and media. The advantage of MRI over ultrasound is that the measurement variability is smaller, enabling smaller sample sizes and potentially shorter study duration in cardiovascular prevention trials.
Duivenvoorden et al. (Fri,) conducted a observational in Cardiovascular disease and carotid atherosclerosis (n=45). 3.0-T MRI vs. B-mode ultrasound was evaluated on Correlation between MRI mean wall thickness and ultrasound intima-media thickness (r=0.89, p=<0.001). 3.0-T MRI measurements of common carotid mean wall thickness were highly correlated with B-mode ultrasound intima-media thickness (r=0.89, P<0.001), with MRI demonstrating smaller variability.