A novel pseudotransient analysis protocol for computing virtual fractional flow reserve generates results in 189 seconds with <1% error relative to full-transient analysis.
Does a novel pseudotransient analysis protocol for computing vFFR reduce computation time while maintaining accuracy compared to full-transient computational fluid dynamics analysis?
A novel steady-state computational fluid dynamics protocol can accurately compute virtual FFR in under 3 minutes, potentially overcoming the computational time barriers of traditional transient analysis.
Fractional flow reserve (FFR)-guided percutaneous intervention is superior to standard assessment but remains underused. The authors have developed a novel "pseudotransient" analysis protocol for computing virtual fractional flow reserve (vFFR) based upon angiographic images and steady-state computational fluid dynamics. This protocol generates vFFR results in 189 s (cf >24 h for transient analysis) using a desktop PC, with <1% error relative to that of full-transient computational fluid dynamics analysis. Sensitivity analysis demonstrated that physiological lesion significance was influenced less by coronary or lesion anatomy (33%) and more by microvascular physiology (59%). If coronary microvascular resistance can be estimated, vFFR can be accurately computed in less time than it takes to make invasive measurements.
Morris et al. (Tue,) conducted a other in Coronary artery disease. Pseudotransient analysis protocol for computing virtual fractional flow reserve (vFFR) vs. Full-transient computational fluid dynamics analysis was evaluated on Computation time and error relative to full-transient analysis. A novel pseudotransient analysis protocol for computing virtual fractional flow reserve generates results in 189 seconds with <1% error relative to full-transient analysis.
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