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MERLOT is an integrated package of computer programs for the determination of initial models of crystal structures using the molecular replacement technique. The package includes two programs for calculating the rotation function, three methods for solving the translation problem (a translation function, a packing function and an R value mapping program) and a program for optimizing a potential solution. The programs are applicable to both macromolecular and small molecule structure determinations. All non-centrosymmetric space groups (excluding rhombohedral and cubic) are provided for.
Paula M.D. Fitzgerald (Wed,) studied this question.