Atrial fibrillation was associated with significantly higher levels of inflammatory markers, including IL-8 (180 vs 39 pg/mL, P<0.001) and TNF-α (26 vs 9 pg/mL, P<0.001), compared to sinus rhythm.
Case-Control (n=106)
Is atrial fibrillation associated with elevated inflammatory markers and CA-125 levels compared to sinus rhythm?
Atrial fibrillation is associated with significant inflammatory activation, and in these patients, CA-125 levels correlate with NYHA functional class and IL-6 levels.
Absolute Event Rate: 180% vs 39%
p-value: p=<0.001
BACKGROUND: Atrial fibrillation (AF) might be associated with an inflammatory activation and reduced left ventricular (LV) function. Less is known with regard to newly introduced markers of LV dysfunction such as carbohydrate antigen-125 (CA-125) in subjects with AF. The aim of this study was therefore to assess possible associations between AF, inflammatory markers and CA-125. METHODS AND RESULTS: Forty-eight consecutive patients with AF and 58 control patients in sinus rhythm were enrolled in this study. Patients with acute heart failure, chronic inflammatory or neoplastic disease were excluded from the study. Circulating levels of hs-C-reactive protein (CRP), interleukin-8 (IL-8), IL-6, soluble IL-2 receptor (sIL-2r), TNF-α and CA-125 were assessed; all patients underwent clinical examination with NYHA class assessment and echocardiography. Patients with AF were characterised by higher levels of IL-8 (180 ± 266 vs. 39 ± 43 pg/mL, P 6 months. CA-125 levels were not statistically different if comparing subjects with AF with controls and AF > 6 months with AF < 6 months. Among patients with AF, CA-125 levels were significantly related to NYHA class, (r = 0·33, P < 0·05) as well as IL-6 levels (r = 0·31, P < 0·05). Results remained statistically significant even after multivariable correction for age, gender and LV ejection fraction. RESULTS AND CONCLUSION: AF is characterised by an inflammatory activation. Impaired functional class in AF subjects might be associated with increased CA-125 levels and higher inflammatory markers.
Gennaro et al. (Wed,) conducted a case-control in Atrial fibrillation (n=106). Atrial fibrillation vs. Sinus rhythm was evaluated on IL-8 levels (pg/mL) (p=<0.001). Atrial fibrillation was associated with significantly higher levels of inflammatory markers, including IL-8 (180 vs 39 pg/mL, P<0.001) and TNF-α (26 vs 9 pg/mL, P<0.001), compared to sinus rhythm.