High arousal threshold in obstructive sleep apnea patients was associated with higher odds of moderate-to-high 10-year cardiovascular disease risk (OR 3.41; 95% CI 1.53-7.61; p=0.003).
Cross-Sectional (n=387)
Is high arousal threshold associated with increased 10-year cardiovascular disease risk in patients with obstructive sleep apnea?
High arousal threshold in patients with obstructive sleep apnea is independently associated with a higher estimated 10-year absolute cardiovascular disease risk.
Effect estimate: OR 3.41 (95% CI 1.53-7.61)
p-value: p=0.003
Abstract Background and objective Obstructive sleep apnea (OSA) has been recognized as one of the risk factors for cardiovascular disease (CVD). OSA patients with high arousal threshold (ArTH) are less easy to arouse, which leads to more severe hypoxic events. In this study, we hypothesized that high ArTH would be a greater risk factor for cardiovascular disease in patients with OSA. Methods We conducted a cross-sectional study of 387 patients with OSA (the average age was 47.0 (37.0, 58.0) years old, 78.81 % male). High ArTH was based on an overnight polysomnography, and defined as none or one of the following conditions: apnea-hypopnea index (AHI) 30 events/hour, minimum oxygen saturation 82.5 %, or frequency of hypopnea events 58.3 %. The Framingham Risk Score (FRS) was used to estimate 10-year absolute CVD risk. FRS was categorized as low (10%), moderate (10-20%), or high (20%), and the CVD FRS risk was defined as dichotomous variables: low risk and moderate-to-high risk in this study. Results Among the 387 OSA patients, 211 (54.52 %) had moderate-to-high cardiovascular disease risk and 266 (68.73 %) had high ArTH. Logistic regression, after adjusting for confounders, showed that patients with high ArTH, especially in non-obese patients, had higher odds for moderate-to-high cardiovascular disease risk (OR = 3.41, 95 % CI = 1.53-7.61, p = 0.003) compared to patients with low ArTH. Moreover, we found that OSA patients with high ArTH have more arousals, particularly respiratory event-related arousals, more apnea events, less hypopnea events and slow wave sleep. Conclusion A high ArTH is independently associated with 10-year absolute CVD risk in patients with OSA. Our findings suggest that high ArTH is an indicator for CVD risk in the future. This abstract is funded by: None
T Han (Fri,) conducted a cross-sectional in Obstructive sleep apnea (n=387). High arousal threshold (ArTH) vs. Low arousal threshold was evaluated on Moderate-to-high 10-year absolute cardiovascular disease risk (Framingham Risk Score ≥10%) (OR 3.41, 95% CI 1.53-7.61, p=0.003). High arousal threshold in obstructive sleep apnea patients was associated with higher odds of moderate-to-high 10-year cardiovascular disease risk (OR 3.41; 95% CI 1.53-7.61; p=0.003).
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