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This research aims to assess the changes in biochemical and hematological parameters due to diabetes in rats.

May 20, 2026Animal Health Production and Hygiene0 citations

Evaluation of Some Biochemical and Hematological Parameters in Experimentally Induced Diabetic Rats

BABeyza Suvarıklı AlanSelçuk University MAMurat ALTINSOYSelçuk University FAFeray AltanDokuz Eylül Üniversitesi Hastanesi

Key Points

This research aims to assess the changes in biochemical and hematological parameters due to diabetes in rats.
33 male Wistar albino rats were randomly divided into control, diabetes, and control+citric acid buffer groups.
Blood samples were collected to measure glucose levels at multiple time points, with analyses conducted after 4 weeks.
Hematological and biochemical parameters were measured from blood and serum samples.
Chloride and CK levels significantly decreased in the diabetes group compared to the control group (p<0.05).
Biochemical alterations indicate potential impacts on metabolic pathways associated with diabetes.
Insulin sensitivity changes and lipid metabolism were noted during the observation period.

Abstract

Diabetes, defined by high blood sugar levels and glycosuria, is characterized by changes in insulin sensitivity, damage to the pancreas, and alterations in lipid and protein metabolism in advanced stages. In this study, 33 male Wistar albino rats were randomly divided into three groups: control, diabetes, and control+citric acid buffer. Blood samples for glucose control were taken from the rat's tail in all groups on days 0, 3, 6, 9, 16, 23, and 30, and from the heart under anesthesia after 4 weeks. Hematological and biochemical parameters were analyzed from blood and serum samples at the specified time intervals and at the end of the experiment, respectively.While chloride and CK levels decreased in the diabetes group compared to the control group (p

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