Can a whole-heart computer model accurately simulate intracardiac potentials for applications in electrophysiology studies and catheter ablation?
Whole-heart computer modeling can effectively simulate intracardiac electrograms, representing a novel approach to studying the electrocardiologic forward problem for EPS and ablation.
Computer simulation of intracardiac potentials was performed based on a whole-heart model, emphasising applications to Electrophysiology Study (EPS) and catheter ablation. A numerical method was proposed based on a volume conductor model with multiple interfaces and piecewise homogeneity. A model of a normal heart and a model of Wolff-Parkinson-White (WPW) Syndrome with a right free-wall Accessory Pathway (AP) were employed to simulate intracardiac electrograms. The study was validated by comparing the simulated electrograms with those in catheter-based EPS and ablations. Applying whole-heart modelling to the EPS and ablation is regarded as a new direction of electrocardiologic forward problem.
Zhu et al. (Sat,) studied this question.