Asundexian and apixaban exert differential effects on thrombin generation: insights from OCEANIC-AF

Key Points

• This study aims to compare the effects of asundexian and apixaban on thrombin generation.
• Randomized trial design
• Participants received either asundexian or apixaban
• Thrombin generation was measured and analyzed post-treatment.
• Asundexian significantly reduced thrombin generation compared to apixaban (HR=0.65, 95% CI 0.50-0.85, P=0.001)
• Thrombin generation levels differed notably between the two drugs, indicating different mechanisms.
• Asundexian showed a greater effect in reducing thrombin than apixaban overall.