A higher baseline organization index of atrial electrograms was associated with termination of paroxysmal AF during mitral isthmus ablation (0.50 vs 0.38, P<0.008).
Observational (n=45)
Does the organization index of atrial electrograms predict the termination of paroxysmal atrial fibrillation during catheter ablation?
A higher organization index of atrial electrograms is associated with the termination of atrial fibrillation during limited catheter ablation, suggesting its utility in anticipating the required extent of ablation.
Absolute Event Rate: 0.45% vs 0.35%
p-value: p=0.009
INTRODUCTION: We hypothesized that the frequency spectra of fibrillatory electrograms may reflect the complexity of activities perpetuating atrial fibrillation (AF). To test this hypothesis, we evaluated the frequency spectra in patients with paroxysmal AF in relation to catheter ablation. METHODS AND RESULTS: This study comprised two protocols: 25 patients undergoing pulmonary vein (PV) isolation in protocol I, and 20 patients undergoing mitral isthmus linear ablation after PV isolation in protocol II. The mean of dominant frequency (DF) and organization index (the ratio of the area under the DF and its harmonics to the total power) were determined from 32-second recordings in the coronary sinus. In protocol I, a PV was considered "driver" of AF if isolation of the PV resulted in termination or slowing of AF (decrease in DF by > or =0.25 Hz). Twenty-one patients had AF termination during four PV isolation. Among these 21 patients, 13 patients with single driving PV showed significantly higher baseline organization index than eight patients with multiple driving PVs (0.45 +/- 0.08 vs 0.35 +/- 0.07, P = 0.009). Patients with multiple driving PVs showed a significant increase in the organization index to 0.45 +/- 0.11 (P < 0.05) after isolation of the initial driving PVs. In protocol II, the baseline organization index was significantly higher in seven patients who had termination of AF during mitral isthmus ablation than 13 patients who did not (0.50 +/- 0.10 vs 0.38 +/- 0.07, P < 0.008). The baseline DF was not associated with outcomes of ablation in both protocols. CONCLUSIONS: A higher organization index of atrial electrograms is associated with termination of AF during limited ablation. This parameter may be useful to anticipate the extent of ablation.
Takahashi et al. (Wed,) conducted a observational in Paroxysmal atrial fibrillation (n=45). Catheter ablation (PV isolation and mitral isthmus linear ablation) was evaluated on Baseline organization index in patients with single vs multiple driving PVs (p=0.009). A higher baseline organization index of atrial electrograms was associated with termination of paroxysmal AF during mitral isthmus ablation (0.50 vs 0.38, P<0.008).