What does this research mean for the field?

Apolipoprotein E deficiency significantly increases susceptibility to endotoxemia and Klebsiella pneumoniae infection in mice. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

April 1, 1999Open Access

Apolipoprotein E knock-out mice are highly susceptible to endotoxemia and Klebsiella pneumoniae infection

Key Result

Apolipoprotein E knock-out mice are highly susceptible to endotoxemia and Klebsiella pneumoniae infection.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

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Cite This Study

Bont et al. (Thu,) reported a other. Apolipoprotein E knock-out mice are highly susceptible to endotoxemia and Klebsiella pneumoniae infection.

synapsesocial.com/papers/6a0eb72453f874f2b222aed4 https://doi.org/https://doi.org/10.1016/s0022-2275(20)32147-7

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Endotoxin tolerance: In vivo regulation of tumor necrosis factor and interleukin-1 synthesis is at the transcriptional level1992 · 86 citations
2A reconstituted, apolipoprotein A-I containing lipoprotein reduces tumor necrosis factor release and attenuates shock in endotoxemic rabbits.1993 · 69 citations
3Reconstituted high-density lipoprotein neutralizes gram-negative bacterial lipopolysaccharides in human whole blood1995 · 213 citations
4Antiinflammatory effects of reconstituted high-density lipoprotein during human endotoxemia.1996 · 394 citations
5Effect of hypertriglyceridemia on endotoxin responsiveness in humans1995 · 58 citations

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