Pomegranate juice supplementation for 5 days significantly reduced the intensity, occurrence, and duration of angina pectoris, as well as serum troponin and malondialdehyde levels.
RCT (n=100)
Randomized
Does 220 mL daily pomegranate juice improve angina symptoms and biomarkers of ischemia in patients with unstable angina or myocardial infarction?
Pomegranate juice supplementation for 5 days may reduce angina symptoms and markers of myocardial injury and oxidative stress in patients with unstable angina or myocardial infarction.
Ischemic heart disease is the leading cause of mortality worldwide. The purpose of this study was to evaluate the cardioprotective effects of pomegranate juice in patients with ischemic heart disease. One hundred patients, diagnosed with unstable angina or myocardial infarction, were randomly assigned to the test and the control groups (n = 50, each). During 5 days of hospitalization, in addition to the conventional medical therapies, the test groups received 220 mL pomegranate juice, daily. During the hospitalization period, the blood pressure, heart rate, as well as the intensity, occurrence, and duration of the angina were evaluated on a regular basis. At the end of the hospitalization period, the serum levels of malondialdehyde, interleukin-6, and tumor necrosis factor alpha were measured in all patients. The levels of serum troponin and high-sensitive C-reactive protein levels were also assayed in patients diagnosed with myocardial infarction. Pomegranate juice caused significant reductions in the intensity, occurrence, and duration of angina pectoris in patients with unstable angina. Consistently, the test patients had significantly lower levels of serum troponin and malondialdehyde. Other studied parameters did not change significantly. The results of this study suggest protective effects of pomegranate juice against myocardial ischemia and reperfusion injury. Copyright © 2017 John Wiley & Sons, Ltd.
Razani et al. (Fri,) conducted a rct in Ischemic heart disease (unstable angina or myocardial infarction) (n=100). Pomegranate juice vs. Conventional medical therapies alone was evaluated on Intensity, occurrence, and duration of angina, and serum levels of malondialdehyde, IL-6, TNF-alpha, troponin, and hs-CRP. Pomegranate juice supplementation for 5 days significantly reduced the intensity, occurrence, and duration of angina pectoris, as well as serum troponin and malondialdehyde levels.
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