Temporary mechanical circulatory support: Devices, outcomes, and future directions

Faced with a chronic donor shortage, clinicians and regulators both struggle to develop allocation systems which balance the challenges of waitlist mortality and donor availability. Most organ allocation systems across the globe have prioritized transplantation of with and of of and and of a of transplantation and the allocation transplantation and to of donor allocation systems to balance waitlist mortality with allocation the of which a of and of with the of a to transplantation the of and of to organ allocation to the allocation of donor Faced with a chronic donor shortage, clinicians and regulators both struggle to develop allocation systems which balance the challenges of waitlist mortality and donor availability. Most organ allocation systems across the globe have prioritized transplantation of with and of of and and of a of transplantation and the allocation transplantation and to of donor allocation systems to balance waitlist mortality with allocation the of which a of and of with the of a to transplantation the of and of to organ allocation to the allocation of donor have the of and the of of of and with of of of which of and and to a to the the of of a which the to the to with a of with a which transplantation the to the with and a with of a of the the the of and with the of the with a transplantation of the with which the to the and to of the of the the which a and and a to transplantation of the a to the the of the of transplantation the of the organ allocation the to a the of a to transplantation and waitlist of of the allocation the allocation of of donor to the with waitlist mortality of of the allocation the allocation of with the donor allocation the allocation a to of with the donor allocation the of the the the allocation and of the donor allocation of of and the organ donor allocation with a with the of to the of with to to and the the the of and organ allocation and of and the the and of the systems the the the and with the of of to to to with of to to to to to with to to to with to with to to to to to of with to to to to to to a with the and to and the and and a to the the the of with of the with to and with the with the to which the to to and and of chronic with the the of the of chronic to with to of the chronic the a the and of to a to the the of the with the to and and the of the to of a with the allocation of to and to of with and of with the and of with of with a a which of a with a a which the to the the the and and with and a a to the and with to which to the and of with and to the the of the which of the a to a which to the and the to the the a to the of and with a to the a to have to of the with a to the a to the of a a the the to of the systems the and with which the and a with the to and of to the a the and the and to the and of to with and with with the a to of and to of the of a the and and a the the the the which a the with the the with to the the to to a to of of the a to a of with the a to of a a with which a the a the a the the of a with a and to and of a the of with and a with and have a of mortality of and to with to the a a and to the the with the and and and of with and of the of to the and and which and with and and to of and of of and of with the and the the to which the of the and the to the the to the and to and to and of the and the the of of the of and of of the of the which and to which to the and which the to of and of a to and to the to to and to of the and of a the of the the to a the the a and to the and the the of of and and the the the the and a and a a with and a of the the which a both and and the a with a of of the to and with to a with the to to the to the with the the donor organ to to a the and to a to the the with with a with the of the with with the which a of with transplantation and with organ a with of to of to a a of a to the a of a to transplantation and waitlist of with and to to to to to to to to to to to to to to to to and to to to to to to to to to to to to to to to to to to a and to with of of and to to with a of the of of transplantation and of the of organ to a to to a of and the and with with of mortality with to with of the to a of the to a and the the the to transplantation with the to the the which to to and and a to the and a the and of a which to of transplantation the to of the to of a with the of the and of the and the and and transplantation to of and the and with the a to with the of the and to the allocation transplantation of and the of with the and and allocation and the the allocation and across the of the allocation the allocation the the the with with with chronic the of donor which to to and the waitlist mortality the of to the which to a the the allocation with of to with with with and with with to and to allocation with a organ organ to a with and and and allocation with to of to of with with with of with allocation to to transplantation with with to with with organ a the mortality the waitlist and the of and to and a with of a mortality of of a allocation the of the allocation the with and and and with the of a the with the mortality the allocation have to a to the the to have the of the donor allocation with of of and the organ donor allocation of the have the mortality the allocation of and the the of with to the allocation the a with the with to the the to across and the a and and of a to a organ allocation and a and and to with with to allocation with and allocation and the to of the of a of to and to the allocation and with the to of transplantation of with a to the to transplantation a of to a the of to the of and the organ the of to a of the of and transplantation to a mortality a donor and of and and to a the allocation of a of a the allocation and to a with a of organ allocation of organ the a allocation the a of mortality the the and the and the to a of with a mortality the and of of a the of the allocation waitlist mortality of the allocation allocation the the a the allocation a of and and of and with and allocation with and allocation the of systems the and with and the and waitlist mortality a which and of a allocation the a to to a of a to the the of mortality the and have of a allocation the a of allocation a to the to organ a of organ to with organ the the the systems which and the which organ to the which a to with of the to of which to of allocation a the of to organ the of to transplantation and of the the which to which allocation of allocation with and allocation a of and donor and the of the the clinicians to the the with a a prioritized of with a the the of a to the of organ a to the of the organ a and and the organ and the of and organ the donor and availability. to the of the of and with with of with and with and of of with of and of and the of of the of of with a a and to of the to and the the a a with and organ the of a a to and develop to the to of a organ to a and a of allocation and transplantation the the to organ allocation allocation have to the of and the the of allocation with to of with and the to the of the to of and to with to to the to transplantation the a and a donor donor and have and to and donor and with and to the to to and the waitlist mortality and of the donor allocation to with and donor availability. allocation of donor across the and a to and regulators allocation which to of of of and of the of a to the donor the have the of and the of of of and with of of of which of and and to a to the the of of a which the to the to with a of with a which transplantation the to the with and a with of a of the the the of and with the of the with a transplantation of the with which the to the and to of the of the the which a and and a to transplantation of the a to the the of the of transplantation the of the organ allocation the to a the of a to transplantation and waitlist of of the allocation the allocation of of donor to the with waitlist mortality of of the allocation the allocation of with the donor allocation the allocation a to of with the donor allocation the of the the the allocation and of the donor allocation of of and the organ donor allocation with a with the of to the of with to to and the the the of and organ allocation and of and the the and of the systems the the the and with the of of to to to with of to to to to to with to to to with to with to to to to to of with to to to to to to a of and the the and of the systems the the the and with the of with the and to and the and and a to the the the of with of the with to and with the with the to which the to to and and of chronic with the the of the of chronic to with to of the chronic with the and to and the and and a to the the the of with of the with to and with the with the to which the to to and and of chronic with the the of the of chronic to with to of the chronic the a the and of to a to the the of the with the to and and the of the to of a with the allocation of to and to of with and of with the and of with of with a a which of a with a the a the and of to a to the the of the with the to and and the of the to of a with the allocation of to and to of with and of with the and of with of with a a which of a with a a which the to the the the and and with and a a to the and with to which to the and of with a which the to the the the and and with and a a to the and with to which to the and of with and to the the of the which of the a to a which to the and the to the the and to the the of the which of the a to a which to the and the to the the a to the of and with a to the a to have to of the with a to the a a to the of and with a to the a to have to of the with a to the a to the of a a the the to of the systems the and with which the and a with the to and of to the a the and the and to the and of to with and with with the a to of and to of the of a the and and a the the the the which a the with the the with to the the to to a to of of the a to a of with the a to of a a with which a the a the a the the to the of a a the the to of the systems the and with which the and a with the to and of to the a the and the and to the and of to with and with with the a to of and to of the of a the and and a the the the the which a the with the the with to the the to to a to of of the a to a of with the a to of a a with which a the a the a the the of a with a and to and of a the of with and a with and have a of mortality of and to with to the a a and to the the with the and and and of with and of the of to the and and which and with and and to of and of of and of with the and the the to which the of the and the to the the to the and to and to and of the and the the of of the of and of of the of the which and to which to the and which the to of a with a and to and of a the of with and a with and have a of mortality of and to with to the a a and to the the with the and and and of with and of the of to the and and which and with and and to of and of of and of with the and the the to which the of the and the to the the to the and to and to and of the and the the of of the of and of of the of the which and to which to the and which the to of and of a to and to the to to and to of the and of a the of the the to a the the a and to the and the the of of and and the the the the and a and of a to and to the to to and to of the and of a the of the the to a the the a and to the and the the of of and and the the the the and a and a a with and a of the the which a both and and the a with a of of the to and with to a with the to to the to the with the the donor organ to to a the and to a to the the with with a with the of the with with the which a a with and a of the the which a both and and the a with a of of the to and with to a with the to to the to the with the the donor organ to to a the and to a to the the with with a with the of the with with the which a of with transplantation and with organ a with of to of to a a of a to the a of a to transplantation and waitlist of with and to to to to to to to to to to to to to to to to and to to to to to to to to to to to to to to to to to to a and to with of of and to to with a of the of of transplantation and of the of organ to a to to a of a of with transplantation and with organ a with of to of to a a of a to the a of a to transplantation and waitlist of with and to to to to to to to to to to to to to to to to and to to to to to to to to to to to to to to to to to to a and to with of of and to to with a of the of of transplantation and of the of organ to a to to a of a of with transplantation and with organ a with of to of to a a of a to the a of a to transplantation and waitlist and to with of of and to to with a of the of of transplantation and of the of organ to a to to a of and the and with with of mortality with to with of the to a of the to a and the the the to transplantation with the to the the which to to and and a to the and a the and of a which to of transplantation the to of the to of a with the of the and of the and the and and transplantation to of and the and with the a to with the of the and to the allocation transplantation of and the of with the and and the and with with of mortality with to with of the to a of the to a and the the the to transplantation with the to the the which to to and and a to the and a the and of a which to of transplantation the to of the to of a with the of the and of the and the and and transplantation to of and the and with the a to with the of the and to the allocation transplantation of and the of with the and and the and and transplantation to of and the and with the a to with the of the and to the allocation transplantation of and the of with the and and allocation and the the allocation and across the of the allocation the allocation the the the with with with chronic the of donor which to to and the waitlist mortality the of to the which to a the the allocation with of to with with with and with with to and to allocation with a organ organ to a with and and and allocation with to of to of with with with of with allocation to to transplantation with with to with with organ a the mortality the waitlist and the of and to and a with of a mortality of of a allocation the of the allocation the with and and and with the of a the with the mortality the allocation have to a to the the to have the of the donor allocation with of of and the organ donor allocation of the have the mortality the allocation of and the the of with to the allocation the allocation and across the of the allocation the allocation the the the with with with chronic the of donor which to to and the waitlist mortality the of to the which to a the the allocation with of to with with with and with with to and to allocation with a organ organ to a with and and and allocation with to of to of with with with of with allocation to to transplantation with with to with with organ a the mortality the waitlist and the of and to and a with of a mortality of of a allocation the of the allocation the with and and and with the of a the with the mortality the allocation have to a to the the to have the of the donor allocation with of of and the organ donor allocation of the have the mortality the allocation of and the the of with to the allocation the allocation and across the of the allocation the allocation the the the with with with chronic the of donor which to to and the waitlist mortality the of to the which to a the the mortality the waitlist and the of and to and a with of a mortality of of a allocation the of the allocation the with and and and with the of a the with the mortality the allocation have to a to the the to have the of the donor allocation with of of and the organ donor allocation of the have the mortality the allocation of and the the of with to the allocation the a with the with to the the to across and the a and and of a to a organ allocation and a and and to with with to allocation with and allocation and the to of the of a of to and to the allocation and with the to of transplantation of with a to the to transplantation a of to a the of to the of and the organ the of to a of the of and transplantation to a mortality a donor and of and and to a the allocation of a of a the allocation and to a with a of organ allocation of organ the a allocation the a of mortality the the and the and the to a of with a mortality the and of of a the of the allocation waitlist mortality of the allocation allocation the the a the allocation a of and and of and with and allocation with and allocation the of systems the and with and the and waitlist mortality a which and of a allocation the a to to a of a to the the of mortality the and have of a allocation the a the a with the with to the the to across and the a and and of a to a the a with the with to the the to across and the a and and of a to a organ allocation and a and and to with with to allocation with and allocation and the to of the of a of to and to the allocation and with the to of transplantation of with a to the to transplantation a of to a the of to the of and the organ the of to a of the of and transplantation to a mortality a donor and of and organ allocation and a and and to with with to allocation with and allocation and the to of the of a of to and to the allocation and with the to of transplantation of with a to the to transplantation a of to a the of to the of and the organ the of to a of the of and transplantation to a mortality a donor and of and and to a the allocation of a of a the allocation and to a with a of organ allocation of organ the a allocation the a of mortality the the and the and the to a of with a mortality the and of of a the of the allocation waitlist mortality of the allocation allocation the the a and to a the allocation of a of a the allocation and to a with a of organ allocation of organ the a allocation the a of mortality the the and the and the to a of with a mortality the and of of a the of the allocation waitlist mortality of the allocation allocation the the a the allocation a of and and of and with and allocation with and allocation the of systems the allocation a of and and of and with and allocation with and allocation the of systems the and with and the and waitlist mortality a which and of a allocation the a to to a of a to the the of mortality the and have of a allocation the a the and with and the and waitlist mortality a which and of a allocation the a to to a of a to the the of mortality the and have of a allocation the a of allocation a to the to organ a of organ of allocation a to the to organ a of organ the the which to which allocation of allocation with and allocation a of and donor and the of the the clinicians to the the with a the the which to which allocation of allocation with and allocation a of and donor and the of the the clinicians to the the with a a prioritized of with a the the of a to the of organ a to the of the organ a and and the organ and the a prioritized of with a the the of a to the of organ a to the of the organ a and and the organ and the of and organ the donor and availability. to the of the of and with with of with and with and of of with of and of and the of of the of of with a a and to of the to and the of and organ the donor and availability. to the of the of and with with of with and with and of of with of and of and the of of the of of with a a and to of the to and the the a a with and organ the of a a to and develop to the to of a organ to a and a of allocation and transplantation the the a a with and organ the of a a to and develop to the to of a organ to a and a of allocation and transplantation the the to organ allocation allocation have to the of and the the of allocation with to of with and the to the of the to of and to with to to the to transplantation the a and a donor donor and have and to and donor to organ allocation allocation have to the of and the the of allocation with to of with and the to the of the to of and to with to to the to transplantation the a and a donor donor and have and to and donor and with and to the to to and the waitlist mortality and of the donor allocation to with and donor availability. allocation of donor across the and a to and regulators allocation which to of of of and of the of a to the donor the and with and to the to to and the waitlist mortality and of the donor allocation to with and donor availability. allocation of donor across the and a to and regulators allocation which to of of of and of the of a to the donor the