Severity of retinal changes in 540 hypertensive patients was associated with worse survival rates and higher incidence of cardiac and renal complications over a 20-year follow-up.
Cohort (n=540)
Do ophthalmoscopic findings predict survival and complications in patients with essential hypertension?
Ophthalmoscopic evaluation of retinal changes serves as a practical and accurate prognostic guide for long-term survival and complications in patients with essential hypertension.
Analysis of data on 540 hypertensive patients grouped according to the retinal criteria of Keith, Wagener, and Barker and followed for at least 20 years, or until death, showed that (1) the survival rate in each ophthalmoscopic group was less than that expected in a normal population of the same age and sex distribution, and was poorer for men than for women, (2) there was a definite relationship between severity of retinal changes (ophthalmoscopic grouping) and survival rate and incidence of cardiac and renal complications of hypertension, and (3) for any given level of diastolic blood pressure the prognosis worsened with increase in severity of retinal changes (from lower to higher ophthalmoscopic grouping). It is concluded that changes in the optic fundi remain the simplest, most practical, and most accurate guide to prognosis in hypertension, with or without complications.
Donald J. Breslin (Mon,) conducted a cohort in Essential Hypertension (n=540). Ophthalmoscopic findings (retinal changes) vs. Normal population / lower severity groups was evaluated on Survival rate and incidence of cardiac and renal complications. Severity of retinal changes in 540 hypertensive patients was associated with worse survival rates and higher incidence of cardiac and renal complications over a 20-year follow-up.