The incidence of ischemic stroke in non-valvular atrial fibrillation patients without anticoagulation exhibited triphasic changes with age, with notable increases in their late 50s and late 70s.
Observational (n=3,455)
Yes
The incidence of ischemic stroke in Japanese patients with non-valvular atrial fibrillation not on anticoagulation increases in a triphasic, stepwise manner with notable jumps in the late 50s and late 70s.
Background: The basis for the specific age threshold for increasing of ischemic stroke in non-valvular atrial fibrillation (NVAF) patients has not been fully evaluated. Methods and Results: We conducted a pooled analysis of 3,588 Japanese NVAF patients without anticoagulation therapy from the Shinken Database (n=1,099), the J-RHYTHM Registry (n=1,002), and the Fushimi AF Registry (n=1,487) to determine the incidence of ischemic stroke by age group; patients aged between 31 and 90 years (n=3,455) were analyzed. During a follow-up period of 1.47 years, 69 ischemic strokes occurred (1.33% per year). The incidence of ischemic stroke exhibited triphasic changes as follows: first, it ranged from 0.00% per year to 0.41% per year across the age groups between 31-35 and 46-50 years. Second, it then rose to 1.58% per year in the 56-60-years age group, remaining around 1% per year across the age groups between 56-60 and 71-75 years, with rates ranging from 0.83% to 1.58% per year. Last, it further increased to 2.35% per year in the 76-80-year age group, remaining around 2.5% per year across the age groups between 76-80 and 86-90 years. Conclusions: The incidence of ischemic stroke in NVAF patients exhibits triphasic changes with age, with notable increases observed in patients aged in their late 50s and late 70s.
Suzuki et al. (Mon,) conducted a observational in Non-valvular atrial fibrillation (NVAF) (n=3,455). The incidence of ischemic stroke in non-valvular atrial fibrillation patients without anticoagulation exhibited triphasic changes with age, with notable increases in their late 50s and late 70s.