Chord-sparing mitral valve replacement showed a trend toward increased contractility (P=0.061) and faster relaxation compared to chord-severing techniques in a canine model.
RCT (n=14)
Does chord-sparing mitral valve replacement improve left ventricular function and torsional deformation compared to chord-severing in a canine model?
Preservation of the mitral subvalvular apparatus during MVR maintains the normal relationship between LV systolic function and torsional deformation, suggesting it acts as a modulator of LV pump performance.
p-value: p=0.061
BACKGROUND: Preservation of the mitral subvalvular apparatus during mitral valve replacement (MVR) has become more popular, in part because of the clinically and experimentally demonstrated more optimal left ventricular (LV) performance after surgery; the mechanisms responsible for this beneficial influence, however, have not been clearly elucidated. METHODS AND RESULTS: Fourteen dogs underwent placement of 26 myocardial markers into the LV and septum. One week later, the animals were studied while awake, sedated, and atrially paced (120 beats per minute) both under baseline conditions and after inotropic stimulation (calcium). The animals then underwent MVR and were randomized into either chord-sparing (MVR-Intact) or chord-severing (MVR-Cut) techniques. Two weeks later, the animals were studied under the same conditions. LV systolic function was assessed by the slope of the end-systolic pressure-volume relation (Ees); early LV diastolic filling was analyzed by the pressure-time constant of relaxation (tau). The instantaneous longitudinal gradient of torsional deformation for the LV (twist) was also calculated, as were the changes in twist with respect to time during systole and early diastole (LV recoil). Intergroup comparison showed a trend toward increased contractility (Ees, P = .061, before versus after MVR), as well as faster relaxation for the MVR-Intact group. Concurrent analysis of LV systolic function and the rate of systolic twist revealed a significant inverse relation, which disappeared after MVR when the chordae were severed. CONCLUSIONS: These observations suggest that the mitral subvalvular apparatus acts as a modulator of LV systolic torsional deformation into LV pump (or ejection) performance.
DeAnda et al. (Wed,) conducted a rct in Mitral valve replacement (n=14). Chord-sparing mitral valve replacement (MVR-Intact) vs. Chord-severing mitral valve replacement (MVR-Cut) was evaluated on Left ventricular systolic function (Ees) and early LV diastolic filling (tau) (p=0.061). Chord-sparing mitral valve replacement showed a trend toward increased contractility (P=0.061) and faster relaxation compared to chord-severing techniques in a canine model.