Key points are not available for this paper at this time.
Transformed cells are subject to elimination through intercellular reactive oxygen/nitrogen species (RONS)‐dependent apoptosis‐inducing signaling. Tumor progression, therefore, requires expression of membrane‐bound catalase. Recent research demonstrates that 1 O 2 can inactivate membrane‐bound catalase, thus, inducing the generation of tumor cell‐derived secondary 1 O 2 and RONS‐dependent apoptosis selectively in tumor cells. Crucially, 1 O 2 signaling can result in self‐perpetuating apoptotic signaling from cell‐to‐cell. It is known that CAP contains 1 O 2 and that certain CAP constituents can generate 1 O 2 in solution. The analysis of model experiments performed with defined RONS implies that CAP‐derived 1 O 2 induces the mechanism through which CAP acts selectively against cancer cells in vitro and tumors in vivo. This hypothesis needs to be tested experimentally in order to establish its validity.
Bauer et al. (Fri,) studied this question.