November 1, 1989Open Access

Recombinant interleukin 4 suppresses the production of interferon gamma by human mononuclear cells.

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Abstract

rIL-4 inhibits the production of IFN-gamma by PBMC stimulated with mitogens or allogeneic cells. The suppression is observed at the protein and at the mRNA level; it is dose and time dependent, and it is abolished by a neutralizing mAb to IL-4. It is suggested that the balance between the production of IL-4 and IFN-gamma may be significantly influenced by the chronological order of activation of their respective gene.

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Peleman et al. (Wed,) studied this question.

synapsesocial.com/papers/6a0ff6fb2badbc352aff0ebe https://doi.org/https://doi.org/10.1084/jem.170.5.1751

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